Mapk8ip3^tm1Rjd
Targeted Allele Detail

Summary

• Symbol: Mapk8ip3^tm1Rjd
• Name: mitogen-activated protein kinase 8 interacting protein 3; targeted mutation 1, Roger J Davis
• MGI ID: MGI:3053053
• Synonyms: Jip3-
• Gene: Mapk8ip3 Location: Chr17:25116480-25155951 bp, - strand Genetic Position: Chr17, 12.53 cM
• Alliance: Mapk8ip3^tm1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85160
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a neomycin resistance cassette. Northern blot analysis demonstrated the loss of the transcript. This was confirmed by immunoblot analysis demonstrating the loss of the protein. (J:85160)

Expression

In Mice Carrying this Mutation:	50 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk8ip3 Mutation: 53 strains or lines available

References

• Original: J:85160 Kelkar N, et al., Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9843-8
• All: 6 reference(s)