Ceacam1^Hv2-r
Spontaneous Allele Detail

Summary

• Symbol: Ceacam1^Hv2-r
• Name: CEA cell adhesion molecule 1; hepatitis virus (MHV-4) resistance
• MGI ID: MGI:3053078
• Synonyms: Ceacam1b
• Gene: Ceacam1 Location: Chr7:25161132-25177028 bp, - strand Genetic Position: Chr7, 13.84 cM
• Alliance: Ceacam1^Hv2-r page

Mutation origin

• Strain of Origin: SJL/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: This allele determines resistance to infection by the A59 strains of mouse hepatitis virus MHV-4, and is found only in the SJL/J strain. The protein encoded by this allele differs in the first 27 of the 108 amino acids of the first Ig domain compared to the susceptible allele. This region is thought to be important for virus binding. (J:3241, J:92495)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ceacam1 Mutation: 45 strains or lines available

Notes

Previously called Mhv-1, Hv2. This locus controls resistance of neurons and macrophages to infection by the JHM and A59 strains of mouse hepatitis virus MHV-4. The allele Ceacam1^Hv2-r determines resistance and has been found only in the SJL/J strain; the strains A/J, C57BL/10, BALB/c, NZB, DBA/2, AKR/J, CBA/J, C3H/He, and SWR are all susceptible to infection (Ceacam1^Hv2-s. Heterozygotes are fully susceptible (J:6451, J:14870, J:7456).

References

• Original: J:701 Dveksler GS, et al., Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. J Virol. 1991 Dec;65(12):6881-91
• All: 8 reference(s)