Vip^tm1Clw
Targeted Allele Detail

Summary

• Symbol: Vip^tm1Clw
• Name: vasoactive intestinal polypeptide; targeted mutation 1, Christopher S Colwell
• MGI ID: MGI:3053090
• Synonyms: VIP^-, VIP KO, VIP/PHI^-
• Gene: Vip Location: Chr10:5589218-5597617 bp, + strand Genetic Position: Chr10, 1.97 cM, cytoband A1
• Alliance: Vip^tm1Clw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86544
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted in reverse orientation into exon 4. PCR confirmed recombination in mutant mice. Immunohistochemistry confirmed the loss of protein in homozygotes. (J:86544)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vip Mutation: 24 strains or lines available

References

• Original: J:86544 Colwell CS, et al., Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R939-49
• All: 48 reference(s)