Nobox^tm1Rajk
Targeted Allele Detail

Summary

• Symbol: Nobox^tm1Rajk
• Name: NOBOX oogenesis homeobox; targeted mutation 1, Aleksandar Rajkovic
• MGI ID: MGI:3053093
• Synonyms: Nobox^-
• Gene: Nobox Location: Chr6:43280608-43286488 bp, - strand Genetic Position: Chr6, 21.17 cM
• Alliance: Nobox^tm1Rajk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92421
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace part of exon 2 and all of exons 3-8, encoding the homeodomain and including the polyadenylation signal, with a Pgk1-HPRT cassette. Southern blot and multiplex PCR confirmed recombination in mice. (J:92421)

Expression

In Mice Carrying this Mutation:	5 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nobox Mutation: 27 strains or lines available

References

• Original: J:92421 Rajkovic A, et al., NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20;305(5687):1157-9
• All: 6 reference(s)