Scn10a^tm2(cre)Jwo
Targeted Allele Detail

Summary

• Symbol: Scn10a^tm2(cre)Jwo
• Name: sodium channel, voltage-gated, type X, alpha; targeted mutation 2, John N Wood
• MGI ID: MGI:3053096
• Synonyms: nav1.8-cre, NaV1.8^Cre, Nav1.8Cre, Scn10a^tm2(cre)Jnw
• Gene: Scn10a Location: Chr9:119437522-119548388 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband distal
• Alliance: Scn10a^tm2(cre)Jwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92442
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Scn10a^tm2(cre)Jwo expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scn10a (MGI:108029)

• Mutation details: Cre recombinase, 3' UTR of Scn10a, and an FRT flanked neo were knocked into the initiator methionine so that Cre replaced the ATG. Crossing with mice expressing Flp recombinase in the germ line excised the floxed neo. Cre expression was observed beginning at embryonic day 14 in small-diameter neurons in dorsal root, trigeminal, and nodose ganglia but absent in nonneuronal and CNS tissues. (J:92442)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scn10a (mouse) Summary of all recombinase alleles driven by Scn10a. Comparative matrix view of recombinase activities Alliance mouse Scn10a gene page

Expression

In Mice Carrying this Mutation:

38 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Scn10a Mutation: 102 strains or lines available

References

• Original: J:92442 Nassar MA, et al., Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12706-11
• All: 123 reference(s)