Scn9a^tm1.1Jwo
Targeted Allele Detail

Summary

• Symbol: Scn9a^tm1.1Jwo
• Name: sodium channel, voltage-gated, type IX, alpha; targeted mutation 1.1, John N Wood
• MGI ID: MGI:3053098
• Synonyms: Nav1.7^-, Scn9a^tm1.1Jnw
• Gene: Scn9a Location: Chr2:66310424-66465306 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn9a^tm1.1Jwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92442
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing Scn9a^tm1Jnw with mice ubiquitously expressing Cre removes exons 14 and 15. Southern blot confirmed recombination in mutants. (J:92442)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn9a Mutation: 121 strains or lines available

References

• Original: J:92442 Nassar MA, et al., Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12706-11
• All: 3 reference(s)