Tnfrsf1a^tm1.1Gkl
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1a^tm1.1Gkl
• Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1.1, George Kollias
• MGI ID: MGI:3053140
• Synonyms: P55^deltaNS
• Gene: Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Tnfrsf1a^tm1.1Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92470
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to delete 15 nucleotides in exon 6 encoding amino acids 202-206. Southern blot and PCR confirmed recombination. Flow cytometry of peritoneal cells indicated that the mutation abolished receptor shedding. Cre-mediated recombination removed the floxed selection cassette. (J:92470)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf1a Mutation: 52 strains or lines available

References

• Original: J:92470 Xanthoulea S, et al., Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med. 2004 Aug 2;200(3):367-76
• All: 4 reference(s)