Plscr3^tm1Sims
Targeted Allele Detail

Summary

• Symbol: Plscr3^tm1Sims
• Name: phospholipid scramblase 3; targeted mutation 1, Peter J Sims
• MGI ID: MGI:3053448
• Synonyms: PLSCR3-, Plscr3^{Gt(Betageo)1Sims}
• Gene: Plscr3 Location: Chr11:69737202-69742884 bp, + strand Genetic Position: Chr11, 42.9 cM
• Alliance: Plscr3^tm1Sims page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A gene trap vector containing pKOS-lacZ/MC1neo (Lexicon Genetics, Woodlands, TX) was inserted to replace the first four exons of the gene. Western blot analysis on platelets, lung, muscle and adipocytes did not detect protein. (J:92404)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plscr3 Mutation: 20 strains or lines available

Notes

ES cell line derived from 129S/SvEvBrd.

References

• Original: J:92404 Wiedmer T, et al., Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13296-301
• All: 2 reference(s)