Apsic1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Apsic1^C57BL/6J
• Name: apomorphine stress induced climbing 1; C57BL/6J
• MGI ID: MGI:3053610
• QTL: Apsic1 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68169

Linkage analysis was performed using 25 BXD/Ty recombinant inbred (RI) strains (derived from progenitor strains C57BL/6J and DBA/2J) to identify QTLs associated with stress. A mapping panel consisting of 1400 polymorphic loci was used to map the QTLs. 10-12 week old RI animals were subjected to repeated stress and administered a low dose of apomorphine, then climbing behavior was assessed. Parental strain DBA/2J exhibits significantly increased climbing behavior after stress and apomorphine administration compared to parental strain C57BL/6J. Apomorphine inhibits climbing behavior but the effect appears to be reduced in DBA/2J.

Significant linkage was detected at 35 cM on mouse Chromosome 7 near D7Ncvs49 (P<0.001). This locus is named Apsic1 (apomorphine stress induced climbing 1).

Apsic2 mapped to 55 cM on mouse Chromosome 9 near D9Ncvs55 (P<0.001).

Apsic3 mapped to 49 cM on mouse Chromosome 10 near D10Mit11 (P<0.001). The Apsic3 interval spans 49 cM - 62 cM and explains 34% of the variance. Potential candidate genes for Apsic3 include Hal (49 cM), Fdpsl5 (51 cM), Kcnc2 (62 cM), and Kcnc3 (62 cM).

Apsic4 mapped to 49 cM on mouse Chromosome 13 near Iapls2-6 (P<0.001). Potential candidate genes for Apsic4 include Crhbp and Arsb.

In addition, several loci showed linkage at the P<0.05 significance level. These are at 48 cM on mouse Chromosome 1 (D1Ncvs43), 26 cM - 32 cM and 57 cM on mouse Chromosome 11 (D11Ncvs48 - Hist3, D11Ncvs79), 41 cM on mouse Chromosome 15 (D15Mit1), and 54 cM on mouse Chromosome 19 (D19Mit6).

References

• Original: J:68169 Cabib S, et al., Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model. Psychopharmacology (Berl). 1997 Jul;132(2):153-60
• All: 1 reference(s)