Apsic3^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Apsic3^C57BL/6J
• Name: apomorphine stress induced climbing 3; C57BL/6J
• MGI ID: MGI:3053614
• QTL: Apsic3 Location: unknown Genetic Position: Chr10, cM position of peak correlated region/allele: 46.97 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68169

Linkage analysis was performed using 25 BXD/Ty recombinant inbred (RI) strains (derived from progenitor strains C57BL/6J and DBA/2J) to identify QTLs associated with stress. A mapping panel consisting of 1400 polymorphic loci was used to map the QTLs. 10-12 week old RI animals were subjected to repeated stress and administered a low dose of apomorphine, then climbing behavior was assessed. Parental strain DBA/2J exhibits significantly increased climbing behavior after stress and apomorphine administration compared to parental strain C57BL/6J. Apomorphine inhibits climbing behavior but the effect appears to be reduced in DBA/2J.

Significant linkage was detected at 35 cM on mouse Chromosome 7 near D7Ncvs49 (P<0.001). This locus is named Apsic1 (apomorphine stress induced climbing 1).

Apsic2 mapped to 55 cM on mouse Chromosome 9 near D9Ncvs55 (P<0.001).

Apsic3 mapped to 49 cM on mouse Chromosome 10 near D10Mit11 (P<0.001). The Apsic3 interval spans 49 cM - 62 cM and explains 34% of the variance. Potential candidate genes for Apsic3 include Hal (49 cM), Fdpsl5 (51 cM), Kcnc2 (62 cM).

Apsic4 mapped to 49 cM on mouse Chromosome 13 near Iapls2-6 (P<0.001). Potential candidate genes for Apsic4 include Crhbp and Arsb.

In addition, several loci showed linkage at the P<0.05 significance level. These are at 48 cM on mouse Chromosome 1 (D1Ncvs43), 26 cM - 32 cM and 57 cM on mouse Chromosome 11 (D11Ncvs48 - Hist3, D11Ncvs79), 41 cM on mouse Chromosome 15 (D15Mit1), and 54 cM on mouse Chromosome 19 (D19Mit6).

References

• Original: J:68169 Cabib S, et al., Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model. Psychopharmacology (Berl). 1997 Jul;132(2):153-60
• All: 1 reference(s)