Npy1r^tm1.1Wpg
Targeted Allele Detail

Summary

• Symbol: Npy1r^tm1.1Wpg
• Name: neuropeptide Y receptor Y1; targeted mutation 1.1, William P Gray
• MGI ID: MGI:3053796
• Synonyms: Y1^-
• Gene: Npy1r Location: Chr8:67149844-67159444 bp, + strand Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
• Alliance: Npy1r^tm1.1Wpg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92582
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Crossing Npy1r^tm1Wpg mice with mice expressing Cre in the germ line excised the entire floxed region containing the coding sequence. Southern blot confirmed recombination. A radioligand binding assay indicated that mutant mice had negligible binding to the Npy1r specific antagonist. (J:92582)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npy1r Mutation: 25 strains or lines available

References

• Original: J:92582 Howell OW, et al., Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J Neurochem. 2003 Aug;86(3):646-59
• All: 22 reference(s)