Tg(WapIgf1)39Dlr
Transgene Detail

Summary

• Symbol: Tg(WapIgf1)39Dlr
• Name: transgene insertion 39, Derek LeRoith
• MGI ID: MGI:3053848
• Transgene: Tg(WapIgf1)39Dlr Location: unknown
• Alliance: Tg(WapIgf1)39Dlr page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(WapIgf1)39Dlr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Igf1 (24482)

  Igf1	(MGI:96432)

• Mutation details: The transgene contains the mouse whey acidic protein promoter and a rat preproIgf1 cDNA (insulin-like growth factor 1), which lacks 186 bp sequence of exon 1 and exon 5. The cDNA encodes 38 bp of 5'UTR, 48 amino acids of the signal peptide, the 70 amino acid mature peptide, the 35 amino acid Ea trailer peptide, and 13 bp of 3'UTR. (J:92578)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:92578 LeRoith D, et al., Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: studies in transgenic mice. Prog Growth Factor Res. 1995;6(2-4):433-6
• All: 2 reference(s)