Lamp1^tm1Psa
Targeted Allele Detail

Summary

• Symbol: Lamp1^tm1Psa
• Name: lysosomal-associated membrane protein 1; targeted mutation 1, Paul Saftig
• MGI ID: MGI:3053864
• Synonyms: Cd107a^-, LAMP-1 -
• Gene: Lamp1 Location: Chr8:13209161-13225338 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: Lamp1^tm1Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54567
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin gene was inserted in exon 3 which created a premature stop codon in the open reading frame. Absence of gene transcript was indicated by Northern blot analysis and western blot analysis confirmed the absence of protein product. (J:54567)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lamp1 Mutation: 29 strains or lines available

References

• Original: J:54567 Andrejewski N, et al., Normal lysosomal morphology and function in LAMP-1-deficient mice. J Biol Chem. 1999 Apr 30;274(18):12692-701
• All: 5 reference(s)