Brmth6^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Brmth6^C57BL/6J
• Name: behavioral response to methamphetamines 6; C57BL/6J
• MGI ID: MGI:3053896
• QTL: Brmth6 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 81.85 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:37546

Linkage analysis was performed on 24 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred strains to identify loci associated with behavioral responses to methamphetamines. Several provisional QTLs were identified. The loci reported here are statistically significant to the level of P=0.001.

On mouse chromosome 1 a locus associated with change in body temperature mapped to 48.4 cM near D1Ncvs41 and a locus associated with climbing activity and body temperature change mapped to 74.5 cM near D1Ncvs12. These loci are designated Brmth1 (behavioral response to methamphetamines 1) and Brmth2, respectively.

On mouse Chromosome 5 a locus associated with chewing behavior mapped to 54 cM near D5Mit10. This locus is designated Brmth3.

On mouse Chromosome 6 loci associated with home cage activity mapped to 6 cM near Met and 31 cM near D6Nds3. These loci are designated Brmth4 and Brmth5, respectively.

On mouse Chromosome 7 a locus associated with home cage activity mapped to 66 cM near D7Mit12. This locus is designatedBrmth6.

On mouse Chromosome 9 a locus associated with home cage activity mapped to 16 cM near Fli1 and a locus associated with body temperature change mapped to 71 cM near D9Byu6. These loci are designated Brmth7 and Brmth8, respectively. The locus at Fli1 was also detected in separate studies by Tolliver et al (1994; J:21289) and Miner and Marley (1995; J:23071).

On mouse Chromosome 14 a locus associated with climbing activity mapped to 12.5 cM near D14Mit54. This locus is designated Brmth9.

On mouseChromosome 17 a locus associated with body temperature change mapped to 10.05 cM near Zfp40. This locus is designated Brmth10.

On mouse Chromosome 19 a locus associated with body temperature change mapped to 9 cM near Pomc1. This locus is designated Brmth11.

References

• Original: J:37546 Grisel JE, et al., Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. J Neurosci. 1997 Jan 15;17(2):745-54
• All: 1 reference(s)