Cplaq13^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Cplaq13^DBA/2J
• Name: circadian period of locomotor activity 13; DBA/2J
• MGI ID: MGI:3053946
• QTL: Cplaq13 Location: Chr1:172831765-181400659 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased circadian locomotor activity compared to C57BL/6J. (J:58134)
• Inheritance: Not Specified

Notes

Congenic strain B6.D2-Mtv7 exhibits decreased circadian locomotor activity compared to background strain C57BL/6J.

Cplaq3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58134

The B6.D2-Mtv7^a/J congenic line was used to verify Cplaq3. This congenic carries DBA/2J-derived DNA at the Mtv7 locus (between 89 cM and 106 cM) on a C57BL/6J genetic background. The congenic region includes Cplaq3 (94.2 cM) and contains DBA/2J-derivedDNA from D1Mit206 to D1Mit273. Parental strain C57BL/6J exhibits greater locomotor activity during the circadian period (longer tauDBX) compared to parental strain DBA/2J (shorter tauDBX). The B6.D2-Mtv7^a/J congenic exhibits decreased circadian locomotor activity compared to the background strain C57BL/6J thus confirming the decreasing effect of DBA/2J-derived alleles.

03.11.2015 Curator Note: Because Cplaq3 was originally mapped in J:36675 in 1995 uisng 13 CXB (BALB/cBy x C57BL/6By) recombinant inbred strains, which differ from the congenic mice used here, we consider the currant study a separate mapping experiment and have named the QTL identified Cplaq13.

Candidate genes found near Cplaq3 are Nhlh1, Kcnj10, Pou2f1, Ddr2, Lmx1a, Vangl2, Atp1b1, Mop3, and Rxrg.

References

• Original: J:58134 Mayeda AR, et al., A QTL for the genetic variance in free-running period and level of locomotor activity between inbred strains of mice. Behav Genet. 1999 May;29(3):171-6
• All: 1 reference(s)