Gli1^{tm3(cre/ERT2)Alj}
Targeted Allele Detail

Summary

• Symbol: Gli1^{tm3(cre/ERT2)Alj}
• Name: GLI-Kruppel family member GLI1; targeted mutation 3, Alexandra L Joyner
• MGI ID: MGI:3053957
• Synonyms: Gli1^CreER, Gli1-CreER^T2, Gli1^CreERT2, Gli1^{tm3(cre/ERT2)Alj}, Gli1^{tm3(cre/ESR1)Alj}
• Gene: Gli1 Location: Chr10:127165751-127177448 bp, - strand Genetic Position: Chr10, 74.5 cM
• Alliance: Gli1^{tm3(cre/ERT2)Alj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92507
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gli1^{tm3(cre/ERT2)Alj} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gli1 (MGI:95727)

• Mutation details: CreERT2 cDNA and a floxed neo were inserted into the 5' UTR of the first coding exon. Crossing with mice expressing Cre removed the floxed neo. Cre expression in mice carrying this allele is induced by treating the mice with tamoxifen. (J:92507)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gli1 (mouse) Summary of all recombinase alleles driven by Gli1. Comparative matrix view of recombinase activities Alliance mouse Gli1 gene page

Tumor Data

List all tumor models in MMHCdb carrying Gli1^{tm3(cre/ERT2)Alj}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gli1 Mutation: 49 strains or lines available

References

• Original: J:92507 Ahn S, et al., Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell. 2004 Aug 20;118(4):505-16
• All: 219 reference(s)