Tg(AQP2-cre)2Dek
Transgene Detail

Summary

• Symbol: Tg(AQP2-cre)2Dek
• Name: transgene insertion 2, Donald E Kohan
• MGI ID: MGI:3054057
• Transgene: Tg(AQP2-cre)2Dek Location: unknown
• Alliance: Tg(AQP2-cre)2Dek page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(AQP2-cre)2Dek expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  AQP2 (359)

  Aqp2	(MGI:1096865)

• Mutation details: This transgene consists of 14 kb from the 5'-flanking region of the human AQP2 driving expression of a modified cre recombinase that includes an SV40 nuclear localization signal and an 11 amino acid herpes simplex virus glycoprotein D epitope tag. Cre expression is seen in the collecting ducts of the kidney, the vas deferens, and the testis including post-meiotic sperm. Paternal inheritance of this transgene results in ubiquitous cre mediated recombination. (J:52357)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	AQP2 (human) Summary of all recombinase alleles driven by AQP2. Comparative matrix view of recombinase activities Alliance human AQP2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:52357 Nelson RD, et al., Expression of an AQP2 Cre recombinase transgene in kidney and male reproductive system of transgenic mice. Am J Physiol. 1998 Jul;275(1 Pt 1):C216-26
• All: 28 reference(s)