Mdmsc1^Comp9
QTL Variant Detail

Summary

• QTL variant: Mdmsc1^Comp9
• Name: modifier of muscularity 1; Comp9
• MGI ID: MGI:3054078
• QTL: Mdmsc1 Location: Chr3:33327201-45916479 bp Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: Comp9

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased muscularity compared to CAST/Ei. (J:85812)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mdmsc1 has a greater effect in female animals compared to male animals.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:85812

Genome scan was performed on animals from a (CAST/Ei x Comp9)F2 intercross population to identify loci modifying the compact muscularity phenotype. A DNA pooling strategy was used for this study. 141 microsatellite markers at an average spacing of 10.4 cM were screened in 138 F2 mice displaying extreme phenotypes. Parental strain Comp9 is an inbred strain carrying the mutation Gdf8^cmpt and exhibits a compact muscularity phenotype. This phenotype was scored using a value of 5 for high muscularity and a value of 1 for low muscularity. A total of 189 F2 animals homozygous for Gdf8^cmpt were used for linkage analysis. In all instances the Comp9-derived allele confers increased muscularity compared to the CAST/Ei-derived allele.

Linkage to muscularity wasdetected on mouse Chromosome 3 between 17 cM (D3Mit206) and 25 cM (D3Mit224). A stronger effect is observed for females compared to males at this locus. This locus is named Mdmsc1 (modifier of muscularity 1).

A male specific muscularity locus was detected on mouse Chromosome 5 between 56 cM (D5Mit239) and 64 cM (D5Mit26). This locus is named Mdmsc2 (modifier of muscularity 2).

A female specific muscularity locus was detected on mouse Chromosome 7 between 23 cM and 26 cM at D7Mit83. This locus is named Mdmsc3 (modifier of muscularity 3). Potential candidates genes for Mdmsc3 are Myod1 (23.5 cM) and Pace4 (28.5 cM).

Linkage to muscularity on mouse Chromosome 11 covered a broad region with 2 peaks between 26 cM (D11Mit24) and 61 cM (D11Mit199). A peak occurs at D11Mit24 between 26 cM and 32 cM and another peak occurs at D11Mit41 between 46 cM and 51 cM. This locus is named Mdmsc4 (modifier of muscularity 4) and may contain 2 separate QTLs.

Linkage to muscularity on mouse Chromosome 16 covered a broad region between 11 cM and 58 cM. A peak occurs at 10.8 cM (D16Mit143) and at 28.2 cM (D16Mit136). This locus is named Mdmsc5 (modifier of muscularity 5) and may contain 2 separate QTLs. A stronger effect is observed for males compared to females. Chrd (chordin), located at 14 cM, is considered a possible candidate gene for this locus.

Linkage to muscularity was detected on mouse Chromosome X between 19 cM and 66 cM. Peak linkage occurs at 34.7 cM (DXMit128). This locus is named Mdmsc6 (modifier of muscularity 6). A stronger effect is observed for males compared to females. Ar (androgen receptor) maps near this locus and is considered a possible candidate gene.

References

• Original: J:85812 Varga L, et al., Mapping modifiers affecting muscularity of the myostatin mutant (Mstn(Cmpt-dl1Abc)) compact mouse. Genetics. 2003 Sep;165(1):257-67
• All: 1 reference(s)