Prnp^tm1Ito
Targeted Allele Detail

Summary

• Symbol: Prnp^tm1Ito
• Name: prion protein; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:3054245
• Synonyms: Prnp-, Prnp⁰, Rikn Prnp-
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^tm1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68801
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the gene open reading frame and the 3' end of intron 2. Western analysis of lysates from cerebra did not detect protein. (J:68801)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 142 strains or lines available

References

• Original: J:68801 Yokoyama T, et al., In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies. J Biol Chem. 2001 Apr 6;276(14):11265-71
• All: 11 reference(s)