Nav2^{Gt(OST125046)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Nav2^{Gt(OST125046)Lex}
• Name: neuron navigator 2; gene trap OST125046, Lexicon Genetics
• MGI ID: MGI:3054375
• Synonyms: Nav2^-, Nav2^Gt1Dwem
• Gene: Nav2 Location: Chr7:48608796-49259838 bp, + strand Genetic Position: Chr7, 31.23 cM
• Alliance: Nav2^{Gt(OST125046)Lex} page

Mutation origin

• Mutant Cell Line: OST125046
• Germline Transmission: Earliest citation of germline transmission: J:92175
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap containing a PGK-neo was inserted between exons 7 and 8. RT-PCR showed this allele to be a hypomorph, expressing the smaller isoform at comparable levels to wild-type while expression of the large isoform is abolished. (J:92175)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST125046	CG536757 ; (MGI Seq Detail)	3' RACE	Chr7:49102152-49102420 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  33 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	117 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nav2 Mutation: 129 strains or lines available

References

• Original: J:92175 Peeters PJ, et al., Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. Brain Res Dev Brain Res. 2004 Jun 21;150(2):89-101
• All: 5 reference(s)