Tg(DM15)26Bew
Transgene Detail

Summary

• Symbol: Tg(DM15)26Bew
• Name: transgene insertion 26, Be Wieringa
• MGI ID: MGI:3054417
• Transgene: Tg(DM15)26Bew Location: unknown
• Alliance: Tg(DM15)26Bew page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(DM15)26Bew expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DMPK (1760)

  Dmpk	(MGI:94906)

• Mutation details: This transgene contains a 14 kb genomic fragment including all of the human DM15 gene and the last exon from the upstream gene DMWD. Two founder lines were generated Tg26 and Tg15 with 25 and 20 copies of the transgene integrated, respectively. Expression is seen in the muscle and smooth muscle containing tissues. Tg26 has a higher level of expression and more severe phenotype compared to Tg15 which has lower expression and a milder version of the same phenotype seen in Tg26. (J:33711)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Younger mice do not exhibit typical symptoms of Dystrophia Myotonica 1 (J:33711), however older mice (11-15 months of age) develop the distinctive traits of Dystrophia Myotonica 1 (J:93614).

References

• Original: J:33711 Jansen G, et al., Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice [see comments]. Nat Genet. 1996 Jul;13(3):316-24
• All: 3 reference(s)