Tg(SREBP1a)7343Reh
Transgene Detail

Summary

• Symbol: Tg(SREBP1a)7343Reh
• Name: transgene insertion 7343, Robert E Hammer
• MGI ID: MGI:3054654
• Synonyms: S+, Tg(SREBF1)2Mbjg, TgSREBP-1a
• Transgene: Tg(SREBP1a)7343Reh Location: unknown
• Alliance: Tg(SREBP1a)7343Reh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SREBP1a)7343Reh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SREBF1 (6720)

  Srebf1

  (MGI:107606)

• Mutation details: The transgene contains human sterol regulatory element binding transcription factor 1 (SREBF1) under control of the phosphoenolpyruvate carboxykinase (Pck1) promoter. Seven lines were created. (J:35770)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:35770 Shimano H, et al., Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a [see comments]. J Clin Invest. 1996 Oct 1;98(7):1575-84
• All: 15 reference(s)