Ptpn13^tm1Wjh
Targeted Allele Detail

Summary

• Symbol: Ptpn13^tm1Wjh
• Name: protein tyrosine phosphatase, non-receptor type 13; targeted mutation 1, Wiljan Hendriks
• MGI ID: MGI:3054733
• Synonyms: PTP-BL^{deltaP/deltaP}, Ptpn13^deltaPTP
• Gene: Ptpn13 Location: Chr5:103573058-103746169 bp, + strand Genetic Position: Chr5, 50.43 cM, cytoband E-F
• Alliance: Ptpn13^tm1Wjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92590
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 42 to 46 were replaced with a neomycin resistance cassette. Northern blot analysis demonstrated that a truncated mRNA was produced which was shorter than normal by 961 bases. The truncated mRNA lacked sequence coding for the catalytic part of the protein. (J:92590)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn13 Mutation: 96 strains or lines available

References

• Original: J:92590 Wansink DG, et al., Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity. Physiol Genomics. 2004 Sep 16;19(1):50-60
• All: 3 reference(s)