Npas1^tm1Slm
Targeted Allele Detail

Summary

• Symbol: Npas1^tm1Slm
• Name: neuronal PAS domain protein 1; targeted mutation 1, Steven L McKnight
• MGI ID: MGI:3054782
• Synonyms: Npas1-
• Gene: Npas1 Location: Chr7:16189643-16210741 bp, - strand Genetic Position: Chr7, 9.14 cM
• Alliance: Npas1^tm1Slm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92610
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A Beta-galactosidase gene was placed in frame with the N-terminal 41 amino acids of the truncated polypeptide. Homozygotes showed intense staining in the dentate gyrus. (J:92610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npas1 Mutation: 18 strains or lines available

References

• Original: J:92610 Erbel-Sieler C, et al., Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13648-53
• All: 5 reference(s)