Ereg^tm1Sawa
Targeted Allele Detail

Summary

• Symbol: Ereg^tm1Sawa
• Name: epiregulin; targeted mutation 1, Senji Shirasawa
• MGI ID: MGI:3054792
• Synonyms: EP^-
• Gene: Ereg Location: Chr5:91222481-91241505 bp, + strand Genetic Position: Chr5, 44.78 cM
• Alliance: Ereg^tm1Sawa page

Pathology of the skin legions in Ereg^tm1Sawa/Ereg^tm1Sawa mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92618
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-5 (90% of the coding region) were replaced with a PGK-neo in the opposite transcriptional orientation. (J:92618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ereg Mutation: 18 strains or lines available

References

• Original: J:92618 Shirasawa S, et al., Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13921-6
• All: 3 reference(s)