Prkaca^tm2Gsm
Targeted Allele Detail

Summary

• Symbol: Prkaca^tm2Gsm
• Name: protein kinase, cAMP dependent, catalytic, alpha; targeted mutation 2, G Stanley McKnight
• MGI ID: MGI:3054825
• Gene: Prkaca Location: Chr8:84699622-84723072 bp, + strand Genetic Position: Chr8, 40.22 cM, cytoband C3
• Alliance: Prkaca^tm2Gsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92616
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: This allele carries a loxP site and a mutation of the translation initiation codon in every reading frame in exon 1b. Western blot confirmed absence of protein in testes and sperm. (J:92616)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkaca Mutation: 22 strains or lines available

References

• Original: J:92616 Nolan MA, et al., Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13483-8
• All: 1 reference(s)