Grin2c^tm1Mwa
Targeted Allele Detail

Summary

• Symbol: Grin2c^tm1Mwa
• Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3); targeted mutation 1, Masahiko Watanabe
• MGI ID: MGI:3054830
• Synonyms: GluRepsilon3^-
• Gene: Grin2c Location: Chr11:115139995-115158069 bp, - strand Genetic Position: Chr11, 80.8 cM
• Alliance: Grin2c^tm1Mwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89405
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the exon encoding the transmembrane segment M4. In situ hybridization confirmed the absence of mRNA in mutant brains. (J:92648)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2c Mutation: 56 strains or lines available

References

• Original: J:92648 Abe M, et al., NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. J Neurosci. 2004 Sep 18;24(33):7292-304
• All: 3 reference(s)