Rxfp1^tm1Aia
Targeted Allele Detail

Summary

• Symbol: Rxfp1^tm1Aia
• Name: relaxin/insulin-like family peptide receptor 1; targeted mutation 1, Alexander I Agoulnik
• MGI ID: MGI:3054831
• Synonyms: Lgr7-, Lgr7^ko, Rfxp1-LacZ, Rxfp1^TG
• Gene: Rxfp1 Location: Chr3:79548918-79645187 bp, - strand Genetic Position: Chr3, 34.94 cM
• Alliance: Rxfp1^tm1Aia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92627
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to create a duplication of the sequence between parts of exons 15-17 and to insert the IRES-LacZ cassette into exon 17. RT-PCR of brain and testis failed to amplify the expected fragment of the distal part of exon 15, indicating the absence of correctly spliced transcripts. (J:92627)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxfp1 Mutation: 53 strains or lines available

References

• Original: J:92627 Kamat AA, et al., Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Endocrinology. 2004 Oct;145(10):4712-20
• All: 7 reference(s)