Rasd1^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Rasd1^tm1Pngr
• Name: RAS, dexamethasone-induced 1; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:3054834
• Synonyms: dexras1^-
• Gene: Rasd1 Location: Chr11:59854007-59855770 bp, - strand Genetic Position: Chr11, 37.81 cM, cytoband B2
• Alliance: Rasd1^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92624
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Nucleotides encoding amino acids 13-227 were replaced with a neomycin resistance gene. The deleted sequence encompassed the GTP binding and hydrolysis domain and the effector loop. Transcripts were undetectable in RT-PCR or Northern blot of mutant brain tissue. (J:92624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasd1 Mutation: 16 strains or lines available

References

• Original: J:92624 Cheng HY, et al., Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 2004 Sep 2;43(5):715-28
• All: 4 reference(s)