Rassf5^tm1Kina
Targeted Allele Detail

Summary

• Symbol: Rassf5^tm1Kina
• Name: Ras association (RalGDS/AF-6) domain family member 5; targeted mutation 1, Tatsuo Kinashi
• MGI ID: MGI:3054868
• Synonyms: RAPL-
• Gene: Rassf5 Location: Chr1:131104147-131172915 bp, - strand Genetic Position: Chr1, 56.91 cM
• Alliance: Rassf5^tm1Kina page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92670
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette (pLNTK) replaced exon 1 in the gene, including the initiation methionine of the protein. Northern blot analysis of spleen showed no detectable mRNA. Immunoblot analysis of spleen and thymus did not detect protein. (J:92670)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rassf5 Mutation: 26 strains or lines available

References

• Original: J:92670 Katagiri K, et al., Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol. 2004 Oct;5(10):1045-51
• All: 5 reference(s)