Tnfrsf13c^tm1Msc
Targeted Allele Detail

Summary

• Symbol: Tnfrsf13c^tm1Msc
• Name: tumor necrosis factor receptor superfamily, member 13c; targeted mutation 1, Martin L Scott
• MGI ID: MGI:3054873
• Synonyms: BAFF-R-
• Gene: Tnfrsf13c Location: Chr15:82105944-82108570 bp, - strand Genetic Position: Chr15, 38.56 cM
• Alliance: Tnfrsf13c^tm1Msc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92676
• Parent Cell Line: E14.2 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A human CD2 reporter gene lacking cytoplasmic residues at the initiating ATG and a neomycin resistance cassette replaced most of the first two exons of coding sequence. RT-PCR analysis of splenic RNA did not detect message. (J:92676)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf13c Mutation: 15 strains or lines available

References

• Original: J:92676 Shulga-Morskaya S, et al., B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J Immunol. 2004 Aug 15;173(4):2331-41
• All: 1 reference(s)