Tnfrsf13c^tm1Mass
Targeted Allele Detail

Summary

• Symbol: Tnfrsf13c^tm1Mass
• Name: tumor necrosis factor receptor superfamily, member 13c; targeted mutation 1, Marc Schmidt-Supprian
• MGI ID: MGI:3054891
• Synonyms: Baff-r^-, BAFFR^-
• Gene: Tnfrsf13c Location: Chr15:82105944-82108570 bp, - strand Genetic Position: Chr15, 38.56 cM
• Alliance: Tnfrsf13c^tm1Mass page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92732
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-recombinase excised a floxed region containing exons 3 and 4. The excised region encoded the entire extracellular and transmembrane domains and part of the cytoplasmic domain. RT-PCR did not detect mRNA in mutants. FACS analysis showed no surface expression of mutant splenic cells. (J:92732)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf13c Mutation: 15 strains or lines available

References

• Original: J:92732 Sasaki Y, et al., TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004 Aug 15;173(4):2245-52
• All: 28 reference(s)