Tcirg1^tm1Utku
Targeted Allele Detail

Summary

• Symbol: Tcirg1^tm1Utku
• Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; targeted mutation 1, Nalan Utku
• MGI ID: MGI:3054898
• Synonyms: TIRC7^-
• Gene: Tcirg1 Location: Chr19:3946050-3957133 bp, - strand Genetic Position: Chr19, 3.62 cM
• Alliance: Tcirg1^tm1Utku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92730
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-8 were replaced with a neomycin resistance gene. Absence of protein was confirmed in T lymphocytes by antibody staining. (J:92730)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcirg1 Mutation: 36 strains or lines available

References

• Original: J:92730 Utku N, et al., TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response. J Immunol. 2004 Aug 15;173(4):2342-52
• All: 1 reference(s)