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Grem1tm1Rmh
Targeted Allele Detail
Summary
Symbol: Grem1tm1Rmh
Name: gremlin 1, DAN family BMP antagonist; targeted mutation 1, Richard M Harland
MGI ID: MGI:3054923
Synonyms: Grem1-, gremlinLacZ, ldgrm
Gene: Grem1  Location: Chr2:113579020-113588993 bp, - strand  Genetic Position: Chr2, 57.43 cM
Alliance: Grem1tm1Rmh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84077
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame, which lies on a single exon, was replaced with an in frame fusion of lacZ with the sequence encoding the first five residues followed by an FRT site flanked neomycin resistance gene cassette. Mice with and without the neo cassette have the same phenotype. LacZ expression in heterozygous mutant mice recapitulates that of wild-type mice. (J:84077)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grem1 Mutation:  19 strains or lines available
Notes
This mutation was determined through complementation analysis to be allelic to Grem1ld-J (J:84077). Heterozygous mutant mice were viable and fertile. Serial skeletal stains of cartilage and bone of heterozygous mutant embryos and newborn mice showed no abnormalities in limb development.
References
Original:  J:84077 Khokha MK, et al., Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet. 2003 Jul;34(3):303-7
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory