Casp8^tm1Wll
Targeted Allele Detail

Summary

• Symbol: Casp8^tm1Wll
• Name: caspase 8; targeted mutation 1, David Wallach
• MGI ID: MGI:3054930
• Synonyms: Casp8^F
• Gene: Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^tm1Wll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92722
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting construct was created to place a loxP site upstream of exon 1 and a floxed neo downstream of exon 2. Transient Cre expression excised the floxed neo. (J:92722)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 45 strains or lines available

References

• Original: J:92722 Kang TB, et al., Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol. 2004 Sep 1;173(5):2976-84
• All: 9 reference(s)