Tg(Ab1TL)1Gru
Transgene Detail

Summary

• Symbol: Tg(Ab1TL)1Gru
• Name: transgene insertion 1, Michael J Grusby
• MGI ID: MGI:3054941
• Transgene: Tg(Ab1TL)1Gru Location: unknown
• Alliance: Tg(Ab1TL)1Gru page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ab1TL)1Gru expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-Ab1 (MGI:103070)

• Mutation details: This beta chain transgene expresses a truncated class II A beta molecules that lack the 13 membrane distal residues. Transgene expression was detected on B cells and stimulated macrophages, with the expression on B cells being about a log unit higher than endogenous expression. Immunoprecipitation of B cell lysates confirmed a truncated I-Abeta chain was being expressed. (J:91341)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:91341 Smiley ST, et al., Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation. Int Immunol. 1995 Apr;7(4):665-77
• All: 1 reference(s)