Tg(Ins2-Insl3)4Imad
Transgene Detail

Summary

• Symbol: Tg(Ins2-Insl3)4Imad
• Name: transgene insertion 4, Ibrahim M Adham
• MGI ID: MGI:3054956
• Transgene: Tg(Ins2-Insl3)4Imad Location: unknown
• Alliance: Tg(Ins2-Insl3)4Imad page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Insl3)4Imad expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Insl3 (MGI:108427)

• Tg(Ins2-Insl3)4Imad expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The rat insulin II promoter drives expression of a genomic mouse Insl3 fragment that contains nucleotides -2 to +1329. Expression of the transgenic protein is seen in the pancreas and testis. Five founders were generated that all produced identical phenotypes. Results were reported for line L4. (J:74295)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:74295 Adham IM, et al., The overexpression of the insl3 in female mice causes descent of the ovaries. Mol Endocrinol. 2002 Feb;16(2):244-52
• All: 3 reference(s)