Tg(Cd152Ig)1Jbs
Transgene Detail
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| Symbol: |
Tg(Cd152Ig)1Jbs |
| Name: |
transgene insertion 1, Jeffrey Bluestone |
| MGI ID: |
MGI:3054966 |
| Synonyms: |
CTLA4-Ig, CTLA-4Ig, CTLA4Ig, sCTLA4, Tg(Cd152Ig) |
| Transgene: |
Tg(Cd152Ig)1Jbs Location: unknown
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| Alliance: |
Tg(Cd152Ig)1Jbs page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Cd152Ig)1Jbs expresses
2 genes
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Mutation details: The transgene contains a mouse Ctla4/Igh-1a fusion cDNA from which a soluble form of the CD152 antigen (CTLA4Ig) is expressed under control of the human keratin 14 (KRT14) enhancer/promoter, which directs expression to basal squamous epithelial cells primarily of the skin, thymus and tongue. Expression is enhanced by inclusion in the construct of most of the human growth hormone gene to provide intronic, 3' non-coding and polyadenylation sequences. Transgenic mice show blood circulating blood levels of CTLA4Ig that are easily detectable by ELISA or functional assays.
(J:35353, J:65045)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:35353 Lenschow DJ, et al., CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity. 1996 Sep;5(3):285-93 |
| All: |
4 reference(s) |
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Analysis Tools
