Pip5k1c^tm1Pdc
Targeted Allele Detail

Summary

• Symbol: Pip5k1c^tm1Pdc
• Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; targeted mutation 1, Pietro De Camilli
• MGI ID: MGI:3054978
• Synonyms: PIPK1gamma-
• Gene: Pip5k1c Location: Chr10:81128797-81155807 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Pip5k1c^tm1Pdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92666
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 2-6, which encode most of the catalytic region of the gene. Western blot analysis of brain extracts from postnatal day 0 did not detect protein in homozygous mice. (J:92666)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pip5k1c Mutation: 41 strains or lines available

References

• Original: J:92666 Di Paolo G, et al., Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature. 2004 Sep 23;431(7007):415-22
• All: 6 reference(s)