Cldn9^nmf329
Chemically induced Allele Detail

Summary

• Symbol: Cldn9^nmf329
• Name: claudin 9; neuroscience mutagenesis facility, 329
• MGI ID: MGI:3055084
• Gene: Cldn9 Location: Chr17:23901558-23903000 bp, - strand Genetic Position: Chr17, 11.99 cM, cytoband A3.3
• Alliance: Cldn9^nmf329 page

Morphological defects at the basal turn of the cochlea in Cldn9^nmf329/Cldn9^nmf329 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered in an ENU mutagenesis screen. A T-to-C single nucelotide substitution in codon 35 is predicted to change the 35th amino acid of the encoded protein from phenylalanine (Phe) to leucine (Leu), located in the first predicted extracellular loop. Immunohistochemistry experiments with a polyclonal antibody that recognizes the unique C-terminus of the protein showed that the mutant protein is expressed in a spatiotemporal manner similar to the normal protein. (J:152154)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cldn9 Mutation: 11 strains or lines available

References

• Original: J:87349 JAX Neuroscience Mutagenesis Facility, Heritable mouse mutants from JAX NMF ENU Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 2 reference(s)