Tg(MGMT)3Bec
Transgene Detail

Summary

• Symbol: Tg(MGMT)3Bec
• Name: transgene insertion 3, Klaus Becker
• MGI ID: MGI:3055098
• Transgene: Tg(MGMT)3Bec Location: unknown
• Alliance: Tg(MGMT)3Bec page

Transgene origin

• Strain of Origin: NMRI

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MGMT)3Bec expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MGMT (4255)

  Mgmt	(MGI:96977)

• Mutation details: Transgene contains a cytokeratin (Ck) promoter that directs skin targeted overexpression of the human DNA repair protein MGMT (O6-methylguanine-DNA methyltransferase). (J:92925)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92925 Becker K, et al., Targeted expression of human O(6)-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis. Cancer Res. 1996 Jul 15;56(14):3244-9
• All: 1 reference(s)