Pymr^NC/JicJcl
QTL Variant Detail

Summary

• QTL variant: Pymr^NC/JicJcl
• Name: Plasmodium yoelli malaria resistance; NC/JicJcl
• MGI ID: MGI:3055100
• QTL: Pymr Location: Chr9:89859058-118767089 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 55.65 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NC/JicJcl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to infection by Plasmodium yoelli relative to the 129X1/SvJMs allele. (J:92924)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:92924

(NC/JicJcl X 129X1/SvJMs) F1 x NC/JicJcl backcross mice were informative in mapping QTL Pymr (Plasmodium yoelli malaria resistance) to mouse Chromosome 9. Seventy six [76] polymorphic markers at an average spacing of 20 cM were used for the genome scan.

The 129X1/SvJMs-derived allele at Pymr confers resistance to P. yoelli with a dominant mode of inheritance. Parental strain 129X1/SvJMs is resistant to infection with P. yoelli where as parental strain NC/JicJcl is susceptible.

The host resistance locuswas designated Pymr for P. yoelii malaria resistance locus. It mapped to the telomeric portion of mouse Chr 9 between D9Mit10 and D9Mit20.

The region contains three potential candidate genes: Tfr (transferrin), Cish (cytokine-inducible SH-2 containingprotein) and Cmkbr4 (chemokine receptor 4).

The mapped position of Pymr is homologous to the human chromosome syntenic region 3q24-26.

References

• Original: J:92924 Ohno T, et al., Chromosomal mapping of the host resistance locus to rodent malaria (Plasmodium yoelii) infection in mice. Immunogenetics. 2001 Dec;53(9):736-40
• All: 1 reference(s)