Tg(DBHn-lacZ)8Rpk
Transgene Detail

Summary

• Symbol: Tg(DBHn-lacZ)8Rpk
• Name: transgene insertion 8, Raj P Kapur
• MGI ID: MGI:3055106
• Synonyms: DBH-lacZ, DBH-nlacZ(2860-8)
• Transgene: Tg(DBHn-lacZ)8Rpk Location: unknown
• Alliance: Tg(DBHn-lacZ)8Rpk page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: A fragment of the human dopamine beta hydroxylase (DBH) gene, extending from a Sma1 site 5.8 kb upstream from the transcription start to an HpaII site 41 bp into the 5' untranslated region of exon 1, was fused to a bacterial beta-galactosidase reporter gene. (J:92929)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This line was generated from founder 2860-8.

LacZ expression is seen in neurons of the locus ceruleus and other classic noradrenergic brain stem nuclei, sympathetic ganglion neurons, and adrenal chromaffin cells. LacZ expression is also observed in neurons of the enteric system, the retina, some sensory and all cranial parasympathetic ganglia, and some diencephalic and telencephalic brain nuclei.

References

• Original: J:92929 Mercer EH, et al., The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron. 1991 Nov;7(5):703-16
• All: 6 reference(s)