Map3k8^tm1Tmat
Targeted Allele Detail

Summary

• Symbol: Map3k8^tm1Tmat
• Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 1, Tetsuya Matsuguchi
• MGI ID: MGI:3055130
• Synonyms: Cot/Tpl2^-
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^tm1Tmat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187216
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the 3' half of exon 2 and the 5' half of exon 3, encoding the ATP-binding domain (residues 123-224). Western blot analysis showed no protein in mutants. (J:92844, J:187216)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 41 strains or lines available

References

• Original: J:187216 Kikuchi T, et al., Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts. J Dent Res. 2003 Jul;82(7):546-50
• All: 7 reference(s)