Rasgrp2^tm1Amg
Targeted Allele Detail

Summary

• Symbol: Rasgrp2^tm1Amg
• Name: RAS, guanyl releasing protein 2; targeted mutation 1, Ann M Graybiel
• MGI ID: MGI:3055135
• Synonyms: CalDAG-GEFI^-
• Gene: Rasgrp2 Location: Chr19:6449370-6465246 bp, + strand Genetic Position: Chr19, 4.58 cM, cytoband A
• Alliance: Rasgrp2^tm1Amg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92864
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A frameshift mutation that results in a premature stop codon at amino acid 37 was introduced via homologous recombination. Immunohistochemistry and western blot analysis confirm the absence of protein in homozygous mutants. (J:92864)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasgrp2 Mutation: 47 strains or lines available

References

• Original: J:92864 Crittenden JR, et al., CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med. 2004 Sep;10(9):982-986
• All: 20 reference(s)