Pla2g6^tm1Turk
Targeted Allele Detail

Summary

• Symbol: Pla2g6^tm1Turk
• Name: phospholipase A2, group VI; targeted mutation 1, John Turk
• MGI ID: MGI:3055154
• Synonyms: IPLA2beta^-
• Gene: Pla2g6 Location: Chr15:79170428-79212590 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Pla2g6^tm1Turk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92835
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 9. Northern blot and Western blot demonstrated lack of transcript and protein in mutant tissues. (J:92835)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g6 Mutation: 66 strains or lines available

Notes

This model of infantile neuroaxonal dystrophy has a later onset in mouse than in human

References

• Original: J:92835 Bao S, et al., Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility. J Biol Chem. 2004 Sep 10;279(37):38194-200
• All: 34 reference(s)