Htr3a^tm1Jul
Targeted Allele Detail

Summary

• Symbol: Htr3a^tm1Jul
• Name: 5-hydroxytryptamine (serotonin) receptor 3A; targeted mutation 1, David Julius
• MGI ID: MGI:3055155
• Synonyms: 5-HT3R-A^-, Htr3a^tm1Bbm
• Gene: Htr3a Location: Chr9:48810513-48822399 bp, - strand Genetic Position: Chr9, 26.53 cM
• Alliance: Htr3a^tm1Jul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92823
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin cassette was inserted in place of exons 7 and 8, which encode the first three putative transmembrane domains of the channel protein. Northern blot and In situ autoradiography demonstrated gene ablation was successful. (J:92823)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr3a Mutation: 36 strains or lines available

References

• Original: J:92823 Zeitz KP, et al., The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci. 2002 Feb 1;22(3):1010-9
• All: 29 reference(s)