Tg(Myl1-Prkag3*R225Q)1Sson
Transgene Detail

Summary

• Symbol: Tg(Myl1-Prkag3*R225Q)1Sson
• Name: transgene insertion 1, Leif Andersson
• MGI ID: MGI:3055157
• Synonyms: R225Q, Tg(Myl1-Prkag3)1Sson, Tg-Prkag3^225Q
• Transgene: Tg(Myl1-Prkag3*R225Q)1Sson Location: unknown
• Alliance: Tg(Myl1-Prkag3*R225Q)1Sson page

Transgene origin

• Strain of Origin: (CBA x C57BL/6J)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myl1-Prkag3*R225Q)1Sson expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prkag3 (MGI:1891343)

• Mutation details: A Myl1 promoter and enhancer drive expression of a full length mouse Prkag3 cDNA with a single missense mutation (R225Q). Expression of the mutated protein was seen in the skeletal muscle. Levels of the endogenous PRKAG3 protein were reduced resulting in no significant change in overall PRKAG3 protein expression. (J:92821)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:92821 Barnes BR, et al., The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem. 2004 Sep 10;279(37):38441-7
• All: 8 reference(s)