Foxp4^tm1Eem
Targeted Allele Detail

Summary

• Symbol: Foxp4^tm1Eem
• Name: forkhead box P4; targeted mutation 1, Edward E Morrisey
• MGI ID: MGI:3055161
• Synonyms: Foxp4^-
• Gene: Foxp4 Location: Chr17:48178058-48235401 bp, - strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Foxp4^tm1Eem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92817
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the majority of the forkhead domain (exons 12 and 13) with a neomycin resistance gene. Immunohistochemistry of mutant embryos confirmed lack of expression. (J:92817)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp4 Mutation: 91 strains or lines available

References

• Original: J:92817 Li S, et al., Advanced cardiac morphogenesis does not require heart tube fusion. Science. 2004 Sep 10;305(5690):1619-22
• All: 2 reference(s)