Tnfaip3^tm1Ama
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm1Ama
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1, Averil Ma
• MGI ID: MGI:3055173
• Synonyms: A20^-
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm1Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo in reverse transcription orientation replaced exons 1-4, encompassing the ATG initiation codon and residues 1-246. (J:92931)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 45 strains or lines available

References

• Original: J:92931 Lee EG, et al., Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science. 2000 Sep 29;289(5488):2350-4
• All: 16 reference(s)