Tnfaip3^tm1Ama
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm1Ama
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1, Averil Ma
• MGI ID: MGI:3055173
• Synonyms: A20^-
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm1Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo in reverse transcription orientation replaced exons 1-4, encompassing the ATG initiation codon and residues 1-246. (J:92931)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama	involves: C57BL/6J
hm2	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama	Not Specified
cx3	Tnf^tm1Gkl/Tnf^tm1Gkl Tnfaip3^tm1Ama/Tnfaip3^tm1Ama	involves: 129S/SvEv * C57BL/6J
cx4	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: C57BL/6J
cx5	Tnfaip3^tm1Ama/Tnfaip3^tm1Ama Tnfrsf1a^tm1Imx/Tnfrsf1a^+	involves: C57BL/6J

Phenotypes:

Affected Systems	hm1	hm2	cx3	cx4	cx5
show or hide all annotated terms
digestive/alimentary system		√
intestinal inflammation		√
growth/size/body		√	√	√	√
decreased body size		√		√	√
cachexia			√	√	√
hematopoietic system		√
increased granulocyte number		√
increased lymphocyte cell number		√
increased macrophage cell number		√
immune system	√	√	√	√	√
increased granulocyte number		√
increased lymphocyte cell number		√
increased macrophage cell number		√
abnormal cytokine secretion	√		√
abnormal inflammatory response	√		√	√	√
increased inflammatory response		√
intestinal inflammation		√
joint inflammation		√
liver inflammation		√
kidney inflammation		√
integument		√
thick dermal layer		√
thick epidermis		√
liver/biliary system		√
liver inflammation		√
mortality/aging		√	√	√	√
increased susceptibility to induced morbidity/mortality		√
premature death		√	√	√	√
postnatal lethality, incomplete penetrance		√
renal/urinary system		√
kidney inflammation		√
skeleton		√
joint inflammation		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 45 strains or lines available

References

• Original: J:92931 Lee EG, et al., Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science. 2000 Sep 29;289(5488):2350-4
• All: 16 reference(s)